反応式
[C:1]([C:3]1[CH:17]=[CH:16][C:6]2[N:7]=[C:8]([NH:10][C:11]([NH:13][CH2:14][CH3:15])=[O:12])[S:9][C:5]=2[CH:4]=1)#[N:2].Cl.NO.C(=O)([O-])[O-:22].[Na+].[Na+]>>[CH2:14]([NH:13][C:11]([NH:10][C:8]1[S:9][C:5]2[CH:4]=[C:3]([C:1]([NH2:2])=[O:22])[CH:17]=[CH:16][C:6]=2[N:7]=1)=[O:12])[CH3:15]参加物
4
実験手順
About 1 g of N-(6-cyano-1,3-benzothiazol-2-yl)-N′-ethylurea was charged into about 30 mL of aqueous alkanol. Added about 0.6 g hydroxylamine hydrochloride and about 0.45 g sodium carbonate then heated to reflux. The solution was refluxed for about 4–8 hours then cooled to room temperature. The precipitate was recovered by filtration and washed well with water. LC/MS indicated a mixture of two products identified as the following after further purification by preparative HPLC:
後処理
- temperaturethen heated to reflux
- temperatureThe solution was refluxed for about 4–8 hours
- filtrationThe precipitate was recovered by filtration
- washwashed well with water
- additiona mixture of two products
- customfollowing after further purification by preparative HPLC
出典と根拠
- ORDレコード
- ord-42e183c75b274ca58d1e4a2d590f020c
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07091227B2
関連ノート
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