Ethyl bromoacetate → Ethyl 2-(4-acetyl-2-methylphenoxy)acetate

HRID 9624

反応式

HRID 9624 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[CH3:11].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[CH3:11])[CH3:24]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetate2 回HCID 10796Cesium carbonate2 回HCID 701354'-Hydroxy-3'-methylacetophenone

生成物 1

HCID 21986544Ethyl 2-(4-acetyl-2-methylphenoxy)acetate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
40 °C

実験手順

1-(4-Hydroxy-3-methylphenyl)ethanone (90 g) and cesium carbonate (216 g) were stirred in acetonitrile (900 ml) at room temperature under nitrogen for 10 minutes. Ethyl bromoacetate (73 ml) was added and the mixture heated to 40° C. for 3 hours. Further ethyl bromoacetate (2.5 ml) and cesium carbonate (1 g) were added and heating continued for a further hour. The cooled reaction was filtered and the filtrate concentrated to give the title compound as a yellow oil.

後処理

  1. temperatureheating
  2. waitcontinued for a further hour
  3. customThe cooled reaction
  4. filtrationwas filtered
  5. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-5d337718b4324e0dae33ac3f4b6f3bab
出典データセット
uspto-grants-2006_08
特許番号
US07091237B2

関連ノート

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