Citric Acid → Guaifenesin

HRID 963209

反応式

HRID 963209 の反応式
O[CH2:2][C:3]([C@H:5]([C@@H:7]([C@@H:9]([CH2:11]O)O)O)[OH:6])=[O:4].C(O)(=O)[CH2:14][C:15](CC(O)=O)([C:17](O)=[O:18])[OH:16].[C:26]([O-])(=O)CC(CC([O-])=O)(C([O-])=O)O.[Na+].[Na+].[Na+]>>[CH3:26][O:6][C:5]1[CH:7]=[CH:9][CH:11]=[CH:2][C:3]=1[O:4][CH2:14][CH:15]([OH:16])[CH2:17][OH:18]

参加物

4

反応物 3

HCID 311Citric AcidHCID 5984D-(-)-FructoseHCID 6224Trisodium citrate

生成物 1

HCID 3516Guaifenesin

実験手順

The maltitol was similarly admixed with Phase F to form Phase G to which the ammonium glycyrrhizinate was added with another about 5 minutes mixing time being used. The flavors and colorants were then admixed, with a mixing time of about 5 minutes, followed by addition of a sufficient amount of liquid fructose to make the desired volume and mixing to homogeneity. The pH value was thereafter adjusted to be between 4 and 5 using a citric acid or sodium citrate solution. This composition provides 100 mg of guaifenesin per 5 mL (teaspoon).

後処理

  1. additionwas added with another about 5 minutes
  2. additionmixing time
  3. customwere then admixed, with a mixing time of about 5 minutes
  4. additionmixing to homogeneity

出典と根拠

ORDレコード
ord-66703a0f2bae41ba8bce66d2de9beb88
出典データセット
uspto-grants-1998_06
特許番号
US05763449

関連ノート

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