Pyridine → HCID 53746252、化合物

HRID 963553

反応式

HRID 963553 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@@H:13]([C:15]([OH:17])=[O:16])[NH2:14])=O)(C)(C)C.N1C=CC=CC=1.[C:24](Cl)(=[O:33])[CH:25]=[CH:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>CN(C)C=O.C(Cl)(Cl)Cl>[C:24]([NH:14][C@H:13]([C:15]([OH:17])=[O:16])[CH2:12][CH2:11][CH2:10][CH2:9][NH2:8])(=[O:33])[CH:25]=[CH:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

6

反応物 3

HCID 1049PyridineHCID 660233-Phenylprop-2-enoyl chlorideHCID 2733283(2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid

生成物 1

HCID 53746252HCID 53746252、化合物

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6228Dimethylformamide溶媒

実験手順

Nε-t-Butoxycarbonyl-L-lysine (2.58 g) was dissolved in 50 ml of dimethylformamide, and 30 ml of anhydrous pyridine was added to the solution. To the mixture was added a solution of cinnamoyl chloride in chloroform (1.665 g/20 ml) was added, and the reaction was carried out at 40° C. The reaction mixture was concentrated to dryness under reduced pressure, the residue was dissolved in 3.6N HCl/dioxane (33 ml) and, after 4 hours of standing, the solution was concentrated under reduced pressure to give the desired compound (2.43 g; hereinafter referred to as compound B).

後処理

  1. additionwas added
  2. customwas carried out at 40° C
  3. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  4. dissolutionthe residue was dissolved in 3.6N HCl/dioxane (33 ml) and, after 4 hours
  5. concentrationthe solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6833cb4d0c1e4459a7473e26f7b6418c
出典データセット
uspto-grants-1998_06
特許番号
US05763504

関連ノート

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