Methyl iodide → 6-Methoxyhexan-1-ol
反応式
[H-].[Na+].[CH2:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][OH:9].[CH3:11]I>O1CCCC1>[CH3:11][O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][OH:10]参加物
5
実験手順
Sodium hydride (NaH) (50%, 6.12 g) suspended in tetrahydrofuran (TEF) (60 ml) was added to a solution of 1,6-hexanediol (15.0 g) in THP (200 ml), and kept at 60° C. until gas evolution stopped. After cooling, a solution of methyl iodide (12 ml) in THF (35 ml) was added and kept overnight at room temperature. The crude product obtaind after the usual work-up was chromatographed to give 6-methoxy-1-hexanol. Yield; 8.16 g
後処理
- customkept at 60° C. until gas evolution
- temperatureAfter cooling
- customThe crude product obtaind after the usual work-up was chromatographed
出典と根拠
- ORDレコード
- ord-d00bb116cd7445fea0314fa08fb5f9b4
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05770759
反応ノート
読み込み中…