(3,5-Di-tert-butylphenyl)methanol → 3,5-Bis(tert-butyl)benzaldehyde

HRID 964927

反応式

HRID 964927 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:12]=1)[CH2:8][OH:9])([CH3:4])([CH3:3])[CH3:2]>O=[Mn]=O.C(Cl)(Cl)Cl>[C:13]([C:11]1[CH:10]=[C:7]([CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:12]=1)[CH:8]=[O:9])([CH3:16])([CH3:15])[CH3:14]

参加物

4

反応物 1

HCID 12660843(3,5-Di-tert-butylphenyl)methanol

生成物 1

HCID 12682533,5-Bis(tert-butyl)benzaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6212Chloroform溶媒

反応条件

温度
25 °C

実験手順

To the crude alcohol from above was added MnO2 and CHCl3 (20 mL). The mixture was stirred overnight at 25° C. and filtered, and the organic solvent was evaporated. The crude residue was purified by flash chromatography on silica gel eluting with 1:6 ethyl acetate-hexane to give 0.3 g of 3,5-di-t-butylbenzaldehyde as a white solid.

後処理

  1. filtrationfiltered
  2. customthe organic solvent was evaporated
  3. customThe crude residue was purified by flash chromatography on silica gel eluting with 1:6 ethyl acetate-hexane

出典と根拠

ORDレコード
ord-18eedb25bce74f04b968f52632084159
出典データセット
uspto-grants-1998_06
特許番号
US05773421

関連ノート

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