Methyl iodide → dimethyl (2R)-2-methoxybutanedioate

HRID 967615ノート

反応式

HRID 967615 の反応式
[CH3:1][O:2][C:3](=[O:11])[C@H:4]([OH:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7].[CH3:12]I>C(#N)C.[Ag]=O>[CH3:1][O:2][C:3](=[O:11])[C@H:4]([O:10][CH3:12])[CH2:5][C:6]([O:8][CH3:9])=[O:7]

参加物

5

反応物 2

HCID 6328Methyl iodideHCID 110626971,4-dimethyl (2R)-2-hydroxybutanedioate

生成物 1

HCID 2192492dimethyl (2R)-2-methoxybutanedioate収率 88%

試薬・触媒・溶媒 2

HCID 92152Silver(II) oxide触媒HCID 6342Acetonitrile溶媒

実験手順

The above (R)-2-hydroxysuccinic acid dimethyl ester was re-dissolved in methyl iodide (100 mL), freshly prepared silver oxide (30.2 g) was added and the mixture was stirred for 24 hours at room temperature. The reaction mixture was diluted with acetonitrile (200 mL), and filtered through celite to remove silver salts and excess silver hydroxide. The filtrate was taken to dryness to leave (R)-2-methoxysuccinic acid dimethyl ester as an oil (23.2 g, 88%).

後処理

  1. filtrationfiltered through celite
  2. customto remove silver salts and excess silver hydroxide

出典と根拠

ORDレコード
ord-2c04621f6c874692b048da5f311e33b1
出典データセット
uspto-grants-2005_10
特許番号
US06953812B2

反応ノート

読み込み中…