2-Acetamidobenzyl alcohol → N-(2-formylphenyl)acetamide

HRID 971307

反応式

HRID 971307 の反応式
[C:1]([NH:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][OH:8])(=[O:3])[CH3:2]>C(Cl)(Cl)Cl.O=[Mn]=O>[C:1]([NH:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 3392922-Acetamidobenzyl alcohol

生成物 1

HCID 326664N-(2-formylphenyl)acetamide収率 73%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6212Chloroform溶媒

実験手順

To a stirred solution of N-acetyl-2-amino-benzylalcohol (20 g) in dry CHCl3 (500 mL) was added MnO2 (160 g, 8 equivalents) and allowed to stir at room temperature for 12 h. The reaction mixture was filtered through celite and concentrated. The crude product was recrystallised from CHCl3/petrol ether to give N-acetyl-2-aminobenzaldehyde (14 g, 73%).

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated
  3. customThe crude product was recrystallised from CHCl3/petrol ether

出典と根拠

ORDレコード
ord-6b72ab55819f44d887a00194ca641705
出典データセット
uspto-grants-2007_12
特許番号
US07312358B2

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