4-Methoxyphenol → Methacryloylglycylglycine

HRID 978179

反応式

HRID 978179 の反応式
[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].[C:10](Cl)(=[O:14])[C:11]([CH3:13])=[CH2:12].[OH-].[Na+].COC1C=CC(O)=CC=1>>[C:10]([NH:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4])(=[O:14])[C:11]([CH3:13])=[CH2:12]

参加物

5

反応物 4

HCID 90154-MethoxyphenolHCID 11163GlycylglycineHCID 13528Methacryloyl chlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 10241886Methacryloylglycylglycine

実験手順

The procedure described above is utilized with 132 g (0.1 mol) of glycylglycine, 105 g of methacryloyl chloride, 80 g of sodium hydroxide and 500 mg of p-methoxyphenol at 0°-5° C. White precipitate is formed from the reaction mixture. The precipitate crystallized from water had a melting point of (192°-196° C.). Yield of product was 150 g (70.8%). NMR (DMSO-d6), 11 gamma (s, 1H, COOH), 7.9 gamma (s, 2H, NH), 5.5 gamma (s, 1H, =CH2C), 5.2 gamma (s, 1H, =CH2), 3.5 gamma (d, 4H, CH2), 2.6 gamma (s, 3H, CH3).

後処理

  1. customWhite precipitate is formed from the reaction mixture
  2. customThe precipitate crystallized from water
  3. customa melting point of (192°-196° C.)

出典と根拠

ORDレコード
ord-7512288f4ae64b6b97219e387bba9822
出典データセット
uspto-grants-1987_05
特許番号
US04663409

関連ノート

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