Sodium Hydroxide → Ethyl octahydro-1H-indole-2-carboxylate
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11].[OH-].[Na+]>FC(F)(F)C(O)=O.CCOCC.[Pt]=O>[NH:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11]参加物
6
実験手順
Dissolve 27.0 g of ethyl indole-2-carboxylate in 250 ml of trifluoroacetic acid. Add 2.05 g of platinum oxide and hydrogenate the mixture at 50 lb/in2 at room temperature. Filter the mixture and concentrate the filtrate in vacuo to give a residue. Suspend the residue in ether and treat with cold dilute sodium hydroxide solution. Dry the organic layer over magnesium sulfate and concentrate it to give octahydro-1H-indole-2-carboxylic acid, ethyl ester, a pale yellow oil.
後処理
- filtrationFilter the mixture
- concentrationconcentrate the filtrate in vacuo
- customto give a residue
- dry with materialDry the organic layer over magnesium sulfate
- concentrationconcentrate it
出典と根拠
- ORDレコード
- ord-d50247a0343b401387d50da22534e74e
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04634689
反応ノート
読み込み中…