Acetonitrile → Hexanenitrile, 4-ethyl-4-methyl-3-oxo-

HRID 980094

反応式

HRID 980094 の反応式
[CH2:1]([C:3]([CH3:10])([CH2:8][CH3:9])[C:4]([O:6]C)=O)[CH3:2].[C:11](#[N:13])[CH3:12].[H-].[Na+]>O1CCCC1>[C:11]([CH2:12][C:4]([C:3]([CH2:1][CH3:2])([CH3:10])[CH2:8][CH3:9])=[O:6])#[N:13]

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 24758Sodium hydrideHCID 521437Butanoic acid, 2-ethyl-2-methyl-, methyl ester

生成物 1

HCID 159096Hexanenitrile, 4-ethyl-4-methyl-3-oxo-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A 16.5 Kg portion of methyl 2-ethylbutyrate was reacted with 60 Kg of n-butyl lithium, diisopropylamine, and 19.1 Kg of methyl iodide to provide 17.4 Kg of methyl 2-ethyl-2-methylbutyrate. A 7.5 Kg portion of the ester thus formed was reacted with 3.25 Kg of acetonitrile and 5.03 g of sodium hydride in 33 liters of tetrahydrofuran to provide 1-ethyl-1-methylpropyl cyanomethyl ketone. The ketone thus formed was reacted with 4.35 Kg of hydroxylamine hydrochloride and 2.54 Kg of sodium hydroxide in 44 liters of water to provide 5.65 Kg of 5-amino-3-(1-ethyl-1-methylpropyl)isoxazole.

出典と根拠

ORDレコード
ord-6ed1e15bfa5742288deec1d7011955f6
出典データセット
uspto-grants-1987_01
特許番号
US04636243

関連ノート

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