Methyl iodide → 6-Methoxy-1,3,3-trimethylindolin-2-one
反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH3:14])([CH3:13])[C:8](=[O:12])[NH:9]2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH3:18]>C1COCC1>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH3:14])([CH3:13])[C:8](=[O:12])[N:9]2[CH3:18])=[CH:5][CH:4]=1参加物
5
実験手順
To a cooled solution (−5°-0° C.) of 6-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-one (600 mg, 3.14 mmol) in THF (10.5 mL) is added 60% NaH (132 mg, 3.30 mmol) and the mixture stirred for 15 min. Add dropwise to the reaction mixture iodomethane (215 μL, 3.45 mmol), the cold bath is removed and stirred for 2 hrs. The reaction is quenched with sat NH4Cl soln, warmed to room temp and diluted with EtOAc.
後処理
- customthe cold bath is removed
- stirringstirred for 2 hrs
- customThe reaction is quenched with sat NH4Cl soln
- additiondiluted with EtOAc
出典と根拠
- ORDレコード
- ord-8d9fa819fa054953a265f03a5b43cc74
- 出典データセット
- uspto-grants-2003_10
- 特許番号
- US06635655B1
反応ノート
読み込み中…