NADPH
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기본 정보
- CAS
53-57-6- 표준 SMILES
NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1- InChIKey
ACFIXJIJDZMPPO-NNYOXOHSSA-N- 분자식
- C21H30N7O17P3
- 평균 분자량
- 745.4 g/mol
개요
NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent. It has a role as a cofactor and a fundamental metabolite. It is a NAD(P)H and a NADP. It is a conjugate acid of a NADPH(4-).
이름 및 식별자
- 우선 이름
- NADPH
- IUPAC
- [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
- 영어명
- NADPH
- 분자식
- C21H30N7O17P3
- 분자량
- 745.42
이름 및 동의어
NADPH53-57-6TPNHDihydronicotinamide-adenine dinucleotide phosphatebeta-NADPHDihydrocodehydrogenase II2646-71-1Reduced triphosphopyridine nucleotideReduced Nicotinamide Adenine Dinucleotide PhosphateNADPH2MFCD00674870381Q4X082D
이름 더 보기
reducedNADPNNa4 saltent-NADPHβ-NADPH-d4NADPH ≥98%Reduced Co IITriphosphopyridine Nu
dihydronicotinamide adenine dinucleotide phosphatereduced nicotinamide-adenine dinucleotide phosphate[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateNicotinamide-adenine dinucleotide phosphate, reducedAdenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamidereduced Coenzyme IIMFCD00036263dihydronicotinamide adenine dinucleotide-P
데이터베이스 식별자
- CAS
물성
구조 계산 물성보충 중
- XLogP
- -6.8
- 극성 표면적
- 364 Ų
- 수소 결합 공여자 수
- 9
- 수소 결합 수용자 수
- 22
- 회전 가능 결합 수
- 13
- 무거운 원자 수
- 48
- 형식 전하
- 0
- 복잡도
- 1,410
실험 및 물리화학적 성질
Chemical ClassesBiological Agents -> Other Biomolecules
DrugsPharmaceuticals -> Listed in ZINC15
Physical DescriptionSolid
Collision Cross Section
240.5 Ų [M+Na-H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
246.7 Ų [M-H]-
물리화학적 성질
- 끓는 점
- 1175.1 · 1175.1±75.0 °C(Predicted)
- 밀도
- 2.28 · 2.28±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 1.13 · 1.13±0.50(Predicted)
- 물리적 상태
- Solid
- 색상
- White to light yellow
- EPA
- Nicotinamide adenine dinucleotide phosphate (53-57-6)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory InformationAdenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'â5'-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummarySee NADP.
안전 데이터
- tsca
- TSCA listed
화학 및 산업
약리 정보
Tissue LocationsAll Tissues
Cellular LocationsCytoplasm
Metabolite Pathways11-beta-hydroxylase deficiency (CYP11B1)
용도 및 제조
UsesThe reduced form of NADP found in living cells; [Merck Index]
General Manufacturing InformationAdenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide: INACTIVE
응용 분야
용도One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the r
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