NADPH

HCID 5884CAS 53-57-6

기본 정보

표준 SMILES: NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1
InChIKey: ACFIXJIJDZMPPO-NNYOXOHSSA-N
분자식: C21H30N7O17P3
평균 분자량: 745.4 g/mol

개요

NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent. It has a role as a cofactor and a fundamental metabolite. It is a NAD(P)H and a NADP. It is a conjugate acid of a NADPH(4-).

이름 및 식별자

우선 이름: NADPH
IUPAC: [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
영어명: NADPH
분자식: C21H30N7O17P3
분자량: 745.42

이름 및 동의어

NADPH53-57-6TPNHDihydronicotinamide-adenine dinucleotide phosphatebeta-NADPHDihydrocodehydrogenase II2646-71-1Reduced triphosphopyridine nucleotideReduced Nicotinamide Adenine Dinucleotide PhosphateNADPH2MFCD00674870381Q4X082D

이름 더 보기

reducedNADPNNa4 saltent-NADPHβ-NADPH-d4NADPH ≥98%Reduced Co IITriphosphopyridine Nu

dihydronicotinamide adenine dinucleotide phosphatereduced nicotinamide-adenine dinucleotide phosphate[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphateNicotinamide-adenine dinucleotide phosphate, reducedAdenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamidereduced Coenzyme IIMFCD00036263dihydronicotinamide adenine dinucleotide-P

데이터베이스 식별자

CAS: 53-57-6
PubChem CID: 5884
DTXSID: DTXSID001018921
ChEMBL: CHEMBL407009
ChEBI: CHEBI:16474
UNII: 381Q4X082D
EC Number: 200-177-6
Nikkaji: J213.537J

물성

구조 계산 물성

XLogP: -6.8
극성 표면적: 364 Å²
수소 결합 공여자 수: 9
수소 결합 수용자 수: 22
회전 가능 결합 수: 13
무거운 원자 수: 48
형식 전하: 0
복잡도: 1,410

실험 및 물리화학적 성질

Chemical ClassesBiological Agents -> Other Biomolecules

DrugsPharmaceuticals -> Listed in ZINC15

Physical DescriptionSolid

Collision Cross Section · 2건

240.5 Å² [M+Na-H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

246.7 Å² [M-H]-

물리화학적 성질

끓는 점: 1175.1 · 1175.1±75.0 °C(Predicted)
밀도: 2.28 · 2.28±0.1 g/cm3(Predicted)
산도 계수 (pKa): 1.13 · 1.13±0.50(Predicted)
물리적 상태: Solid
색상: White to light yellow
EPA: Nicotinamide adenine dinucleotide phosphate (53-57-6)

안전 및 규제

유해성 정보

Regulatory InformationAdenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'â5'-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummarySee NADP.

안전 데이터

tsca: TSCA listed

화학 및 산업

약리 정보

Tissue LocationsAll Tissues

Cellular LocationsCytoplasm

Metabolite Pathways11-beta-hydroxylase deficiency (CYP11B1)

용도 및 제조

UsesThe reduced form of NADP found in living cells; [Merck Index]

General Manufacturing InformationAdenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide: INACTIVE

응용 분야 · 1건

용도One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the r

상·하류 제품 정보

상류 원료

하류 제품

5-아미노-2,5-디옥소-펜탄산

공급사40 곳

上海摩睿化学科技有限公司13382110328 15255501563 · [email protected]

Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

曼顿生物科技（深圳）有限公司+86-75589664337 +86-15112661142 · [email protected]

Hong Kong Tiansheng New Material Trading Co., Ltd+8617320695765 · [email protected]

추가 설명 · 1건

정의A coenzyme composed of ribosylnicotinamide 5′- phosphate coupled by pyrophosphate linkage to the 5′-phosphate adenosine 2′,5′-bisphosphate. The reduced from of NADP. It is an energy-storage form that can be transferred to the Calvin cycle where it participates in the production of carbohydrate.