Glyoxylic Acid → 4-Hydroxyphenylglycine

HRID 46942

반응식

HRID 46942 반응식
[C:1]([OH:5])(=[O:4])[CH:2]=O.C([O-])(=O)C.[NH4+:10].[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[CH:13]1[C:14]([CH:2]([NH2:10])[C:1]([OH:5])=[O:4])=[CH:15][CH:16]=[C:11]([OH:17])[CH:12]=1

참가 물질

5

반응물 3

HCID 760Glyoxylic AcidHCID 996PhenolHCID 517165Ammonium Acetate

생성물 1

HCID 921434-Hydroxyphenylglycine수율 28.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

30 g of an aqueous 40% glyoxylic acid solution are added to 70 ml of water, and 37.5 g of ammonium acetate and 22.5 g of phenol are added thereto under stirring. The mixture is stirred at room temperature for 41 hours. The crystalline precipitates are collected by filtration under cooling, and then successively washed with water and methanol. 7.8 g of DL-p-hydroxyphenylglycine are thereby obtained as white crystals. Yield: 28.9%, M.p. 225°-228° C. (decomp.).

후처리

  1. additionare added
  2. stirringThe mixture is stirred at room temperature for 41 hours
  3. customThe crystalline precipitates
  4. filtrationare collected by filtration
  5. temperatureunder cooling
  6. washsuccessively washed with water and methanol

출처 및 근거

ORD 기록
ord-4a71fba6378949a183990fe45aff8c26
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175206

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