Azobisisobutyronitrile → 6-(Bromomethyl)benzo[d]oxazole
반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][O:8][C:4]=2[CH:3]=1.[Br:11]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)Cl>[Br:11][CH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][O:8][C:4]=2[CH:3]=1참가 물질
5
실험 절차
A mixture of 6-methylbenzoxazole (5.0 g; J. T. Gupton, K. F. Correia and B. S. Foster, Synthetic Communications, 1986, 16, 365), N-bromosuccinimide (7.0 g) and azobisisobutyronitrile (0.55 g) in dry chloroform (100 ml) was heated at reflux for 1 hour. The cooled reaction mixture was washed three times with water (40 ml), dried over magnesium sulphate and evaporated. The residual orange coloured viscous solid was triturated twice with pentane (50 ml) affording the title compound (6.20 g) as a buff coloured solid, m.p. 52-56° C.
후처리
- temperaturewas heated
- temperatureat reflux for 1 hour
- customThe cooled reaction mixture
- washwas washed three times with water (40 ml)
- dry with materialdried over magnesium sulphate
- customevaporated
- customwas triturated twice with pentane (50 ml)
출처 및 근거
- ORD 기록
- ord-73ba69673ea74b60b537ac0003fae1a0
- 출처 데이터셋
- uspto-grants-2000_04
- 특허 번호
- US06048893
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