Citric Acid → Florfenicol Flunixin

HRID 1006518

반응식

HRID 1006518 반응식
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)C(O)C.C1OCOC1CO.[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:67])([F:66])[F:65].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>CC(N(C)C)=O.CN1C(=O)CCC1>[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:66])([F:65])[F:67]

참가 물질

8

반응물 5

HCID 311Citric AcidHCID 1030Propylene GlycolHCID 216181,3-Dioxolane-4-methanol2회HCID 39212Flunixin MeglumineHCID 114811Florfenicol

생성물 1

HCID 86602307Florfenicol Flunixin

시약·촉매·용매 2

HCID 13387N-methyl-2-pyrrolidone용매HCID 31374Dimethylacetamide용매

실험 절차

The NMP or dimethylacetamide, citric acid, propylene glycol, and approximately 90% of the PEG 300 or glycerol formal required for each formulation were charged to the compounding vessel and mixed well. The florfenicol and flunixin meglumine were added with mixing until all solids were dissolved. The volume was adjusted with the remaining PEG 300 or glycerol formal.

후처리

  1. additionwere charged to the compounding vessel
  2. additionmixed well
  3. additionwith mixing until all solids
  4. dissolutionwere dissolved

출처 및 근거

ORD 기록
ord-f638f5ccb58744b6a54966745a9c9f47
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790867B2

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