Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine
반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:10].[C:11]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12].[OH-].[Na+]>C1(O)C=CC=CC=1>[C:11]([C:15]1[CH:16]=[CH:17][C:18]([NH:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=2[O:9][CH3:10])=[CH:20][CH:21]=1)([CH3:14])([CH3:12])[CH3:13]참가 물질
5
실험 절차
7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%
후처리
- temperatureAfter cooling
- extractionthe product is extracted
- concentrationAfter concentrating
- distillationthe excess of amine is distilled off in vacuo
- customthe residue is crystallized
출처 및 근거
- ORD 기록
- ord-ed5d30e63cae482aa9ed8a44a63361f9
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723450
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