Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

HRID 1010

반응식

HRID 1010 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:10].[C:11]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12].[OH-].[Na+]>C1(O)C=CC=CC=1>[C:11]([C:15]1[CH:16]=[CH:17][C:18]([NH:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=2[O:9][CH3:10])=[CH:20][CH:21]=1)([CH3:14])([CH3:12])[CH3:13]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 698614-Tert-ButylanilineHCID 105830464-Chloro-3-methoxy-2-methylpyridine

생성물 1

HCID 196939534-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

시약·촉매·용매 1

HCID 996Phenol용매

실험 절차

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

후처리

  1. temperatureAfter cooling
  2. extractionthe product is extracted
  3. concentrationAfter concentrating
  4. distillationthe excess of amine is distilled off in vacuo
  5. customthe residue is crystallized

출처 및 근거

ORD 기록
ord-ed5d30e63cae482aa9ed8a44a63361f9
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723450

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