Nitric Acid → 6-Methyl-5-nitroquinoline

HRID 1017128

반응식

HRID 1017128 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.S(=O)(=O)(O)O.[N+:17]([O-])([OH:19])=[O:18].[OH-].[Na+]>>[N+:17]([C:3]1[C:2]([CH3:1])=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[N:8]2)([O-:19])=[O:18]

참가 물질

5

반응물 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 70596-MethylquinolineHCID 14798Sodium Hydroxide

생성물 1

HCID 900096-Methyl-5-nitroquinoline

실험 절차

2.45 mol of 6-methylquinoline were added to 1 l of concentrated sulfuric acid, and 2.94 mol of 65% strength nitric acid were added dropwise at from 0 to 10° C. The mixture was stirred for one hour, poured onto ice, adjusted to pH 2.5 using aqueous sodium hydroxide solution, filtered off with suction, washed with water and dried over magnesium sulfate.

후처리

  1. additionwere added dropwise at from 0 to 10° C
  2. additionpoured onto ice
  3. filtrationfiltered off with suction
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-fba0f63ffa8d41a3a1766704edbaa66d
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479436B1

연결된 노트

불러오는 중…