1-Iodooctane → HCID 53772942, 화합물

HRID 1069599

반응식

HRID 1069599 반응식
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[NH:8][C:7]=1[CH3:17])[CH3:2].[H-].[Na+].I[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:7]=1[CH3:17])[CH3:2]

참가 물질

4

반응물 3

HCID 123801-IodooctaneHCID 24758Sodium hydrideHCID 10729163Ethyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate

생성물 1

HCID 53772942HCID 53772942, 화합물수율 51.5%

실험 절차

Using the procedure described in Example 50, Part A, 2.47 g (0.01 mol) of 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester was reacted with 0.48 g (0.012 mol) of 60% NaH/mineral oil and then 2.17 mL (0.012 mol of iodooctane. The product was chromatographed on silica gel and eluted with 5% EtOAc/toluene to give 1.85 g (51% yield) of 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester as an oil.

후처리

  1. customThe product was chromatographed on silica gel
  2. washeluted with 5% EtOAc/toluene

출처 및 근거

ORD 기록
ord-a0b2dd99105f4b3f893c474cfc89ab4b
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06252084B1

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