Water → HCID 22253670, 화합물

To a stirring mixture of 2-aminoisobutyric acid (52.08 g; 0.51 mol), sodium hydroxide (20.20 g; 0.51 mol), 200 mL water and 50 mL chloroform cooled to −12° C., was added a solution of 2-bromopropionyl bromide (100 g; 0.463 mol) in 150 mL chloroform. The temperature was maintained between −15 to −12° C. during the addition. The reaction mixture was then allowed to warm to room temperature and stirred for 17 hours. The precipitated solid was filtered, mixed with 700 mL hot toluene, then cooled to room temperature. The solid was filtered and dried under vacuum to afford 77.6 g (70%) of product.

1. temperatureThe temperature was maintained between −15 to −12° C. during the addition
2. temperatureto warm to room temperature
3. filtrationThe precipitated solid was filtered
4. additionmixed with 700 mL hot toluene
5. temperaturecooled to room temperature
6. filtrationThe solid was filtered
7. customdried under vacuum

ORD 기록

ord-d4f22a448e564e43a9fb082e557bf200

출처 데이터셋

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06911510B2