Hydrochloric Acid → HCID 178478461, 화합물

HRID 1086238노트

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HRID 1086238 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]#[N:6].[N-:7]=[N+:8]=[N-:9].[Na+].[Cl-].[Al+3].[Cl-].[Cl-].Cl.N=[N+]=[N-]>O1CCCC1>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:9][N:8]=[N:7][N:6]=1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 123364-ChlorobutyronitrileHCID 24530Hydrazoic acidHCID 33557Sodium AzideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 178478461HCID 178478461, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.

후처리

  1. temperatureis refluxed for 24 hours
  2. customgenerated is removed by means of an aspirator
  3. customThe organic and aqueous layers are then separated
  4. extractionthe aqueous layer extracted with ethylacetate
  5. dry with materialThe combined organic extracts are dried (magnesium sulfate)
  6. customevaporated

출처 및 근거

ORD 기록
ord-a33f967621004de6b211a17258574739
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05028615

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