Chloroacetic Acid → 2-(4-Chloro-2-methoxyphenoxy)acetic acid

HRID 11613

반응식

HRID 11613 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([O:11][CH3:12])[CH:5]=1.Cl[CH2:14][C:15]([OH:17])=[O:16].Cl>O>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:14][C:15]([OH:17])=[O:16])=[C:6]([O:11][CH3:12])[CH:5]=1

참가 물질

6

반응물 4

HCID 300Chloroacetic AcidHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 280504-Chloroguaiacol

생성물 1

HCID 116585842-(4-Chloro-2-methoxyphenoxy)acetic acid수율 120%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
95 °C

실험 절차

To a solution of sodium hydroxide (6.6 g, 160 mmol) in water (45 mL) was added 4-chloro-2-methoxy-phenol (2.0 mL, 16 mmol) and chloroacetic acid (7.7 g, 81 mmol). The resulting mixture was heated to 95° C. and stirred for three hours. The reaction was allowed to cool to ambient temperature and slowly acidified with concentrated hydrochloric acid (10 mL) until the mixture became a solution and then extracted with diethyl ether. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo to give the title compound (4.16 g).

후처리

  1. temperatureto cool to ambient temperature
  2. extractionextracted with diethyl ether
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b437499df33d48f784286683f8fd74db
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098212B2

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