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Succinic anhydride → Succinic acid mono-{1-[2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-yl}ester

HRID 1161695
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인쇄 미리보기

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HRID 1161695 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([N:17]3[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]3)[CH:14]=[C:13]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:30]1(=[O:36])[O:35][C:33](=[O:34])[CH2:32][CH2:31]1>CN(C1C=CN=CC=1)C.ClC(Cl)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([N:17]3[CH2:18][CH2:19][CH:20]([O:23][C:30](=[O:36])[CH2:31][CH2:32][C:33]([OH:35])=[O:34])[CH2:21][CH2:22]3)[CH:14]=[C:13]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 7922Succinic anhydrideHCID 116401801-[2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol

생성물 1

HCID 58626135Succinic acid mono-{1-[2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-yl}ester

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 63651,1-Dichloroethane용매

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온도
30 °C

실험 절차

A mixture of compound 1-[2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol (1.0 g, 2.4 mmol), 4-(N,N-dimethyl)aminopyridine (0.45 g, 3.66 mmol) and succinic anhydride (0.73 g, 7.33 mmol) in dichloroethane (20 mL) was stirred at refluxing temperature for 48 hours. The mixture was cooled to temperature in the range of 20-40° C. and solvent was removed under reduced pressure. The residue was treated with water (20 mL) and the solid precipitated was filtered and washed with isopropanol to give the desired product.

후처리

  1. temperatureat refluxing temperature for 48 hours
  2. customwas removed under reduced pressure
  3. additionThe residue was treated with water (20 mL)
  4. customthe solid precipitated
  5. filtrationwas filtered
  6. washwashed with isopropanol

출처 및 근거

ORD 기록
ord-5ad261521acf4df8829029f6c5d9ea8e
출처 데이터셋
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07820654B2

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