홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 2-(3'-Amino-4'-sulfophenylamino)-4-chloro-6-(beta-vinylsulfonylethylamino)-1,3,5-triazine

HRID 1165284
노트
인쇄 미리보기

반응식

HRID 1165284 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[C:4]([NH2:12])[CH:3]=1.Cl[C:14]1[N:19]=[C:18](Cl)[N:17]=[C:16]([Cl:21])[N:15]=1.Cl.[OH-].[Na+].Cl.Cl[CH2:27][CH2:28][S:29]([CH2:32][CH2:33][NH2:34])(=[O:31])=[O:30]>O>[NH2:12][C:4]1[CH:3]=[C:2]([NH:1][C:18]2[N:17]=[C:16]([Cl:21])[N:15]=[C:14]([NH:34][CH2:33][CH2:32][S:29]([CH:28]=[CH2:27])(=[O:31])=[O:30])[N:19]=2)[CH:7]=[CH:6][C:5]=1[S:8]([OH:11])(=[O:9])=[O:10]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 7954Cyanuric chlorideHCID 14798Sodium Hydroxide2회HCID 666232,4-Diaminobenzenesulfonic acidHCID 193848642-(2-Chloroethanesulfonyl)ethylaminehydrochloride

생성물 1

HCID 198628912-(3'-Amino-4'-sulfophenylamino)-4-chloro-6-(beta-vinylsulfonylethylamino)-1,3,5-triazine

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

18.8 parts of 1,3-diaminobenzene-4-sulfonic acid are dissolved in 100 parts of water under neutral conditions. This solution is added dropwise in the course of 10 minutes to a mixture of 200 parts of ice and water, 18.5 parts of 2,4,6-trichloro-1,3,5-triazine and 10 parts of 37% hydrochloric acid. The reaction mixture is held at pH 1.5 until the condensation has ended by the continuous addition of 2N sodium hydroxide solution. After the addition of 22.9 parts of β-(β-chloroethylsulfonyl)-ethylamine hydrochloride, the temperature of the reaction mixture is gradually raised from 5° C. to 20° C. while the reaction mixture is initially held at pH 6.5 and then at pH 8.0 by the continuous addition of 2N sodium hydroxide solution. After the condensation and elimination reaction has ended, this reaction mixture is used directly for the acid coupling in Example 4.

후처리

  1. temperaturethe temperature of the reaction mixture is gradually raised from 5° C. to 20° C. while the reaction mixture
  2. customAfter the condensation and elimination reaction

출처 및 근거

ORD 기록
ord-451e6749f9cf49fcab34d87763a7fbfa
출처 데이터셋
uspto-grants-1990_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04908436

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트