Hydrochloric Acid → Succinic Acid Monohex-3-enyl Ester

HRID 1169184노트

반응식

HRID 1169184 반응식
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[CH2:8]([OH:14])[CH2:9]/[CH:10]=[CH:11]\[CH2:12][CH3:13].N1C=CC=CC=1.Cl>ClCCl.CN(C1C=CC=CN=1)C.CCOCC>[CH2:8]([O:14][C:4](=[O:5])[CH2:3][CH2:2][C:1]([OH:6])=[O:7])[CH2:9][CH:10]=[CH:11][CH2:12][CH3:13]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 7922Succinic anhydrideHCID 52811673-Hexenol

생성물 1

HCID 86586591Succinic Acid Monohex-3-enyl Ester수율 92.5%

시약·촉매·용매 3

HCID 218852-Dimethylaminopyridine촉매HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

A mixture of 100 g succinic anhydride, 100 g cis-3-hexen-1-ol, 88.5 ml pyridine and 7.3 g dimethylaminopyridine in 500 ml dichloromethane was refluxed for 4 hours. Ether was added and the mixture was acidified with HCl 2N then washed with brine. The organic layer was dried over magnesium sulfate and concentrated. The residue was distilled under vacuum to afford 185 g of product.

후처리

  1. temperaturewas refluxed for 4 hours
  2. washthen washed with brine
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated
  5. distillationThe residue was distilled under vacuum

출처 및 근거

ORD 기록
ord-f203c64541b642648833c4516183aeff
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627763B2

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