1-(Aminomethyl)cyclohexan-1-ol → 1-Oxa-3-azaspiro(4.5)decan-2-one
반응식
[NH2:1][CH2:2][C:3]1([OH:9])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[C:10]([O:14]C(OC(OC(C)(C)C)=O)=O)(C)(C)C>CN(C)C1C=CN=CC=1.C(#N)C.C(O)(=O)C.Cl>[O:9]1[C:3]2([CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:2][NH:1][C:10]1=[O:14]참가 물질
7
실험 절차
0.65 g (5.0 mmol) of 1-(aminomethyl)-cyclohexanol, 1.2 g (5.5 mmol) di-tert.-butyldicarbonate ((Boc)2O) and 0.611 g 4-dimethylaminopyridine were dissolved in 50 ml acetonitrile and agitated overnight at room temperature. The mixture was then fully turned over, the residue was dissolved in 20 ml acetic acid and again turned over. The residue was taken up in 25 ml 1 M hydrochloric acid and extracted with 50 ml toluene.
후처리
- extractionextracted with 50 ml toluene
출처 및 근거
- ORD 기록
- ord-7ac8cd96d6e54722932bd77cad796e30
- 출처 데이터셋
- uspto-grants-2007_10
- 특허 번호
- US07282515B2
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