Sodium Hydroxide → HCID 178454398, 화합물

HRID 12067

반응식

HRID 12067 반응식
C(N(C(C)C)CC)(C)C.[CH:10]([CH2:12][C:13]([OH:15])=O)=[CH2:11].N1C2C=CC=C(O[P+](N(C)C)(N(C)C)N(C)C)C=2N=N1.F[P-](F)(F)(F)(F)F.Cl.Cl.[N:45]1[C:53]2[CH2:52][CH2:51][NH:50][CH2:49][C:48]=2[S:47][C:46]=1[NH:54][C:55]([NH2:57])=[NH:56].[OH-].[Na+]>CN(C)C=O>[C:13]([N:50]1[CH2:51][CH2:52][C:53]2[N:45]=[C:46]([NH:54][C:55]([NH2:57])=[NH:56])[S:47][C:48]=2[CH2:49]1)(=[O:15])[CH2:12][CH:10]=[CH2:11]

참가 물질

7

반응물 5

HCID 14798Sodium HydroxideHCID 327433-Butenoic acidHCID 81531DiisopropylethylamineHCID 178478794HCID 178478794, 화합물HCID 178486078HCID 178486078, 화합물

생성물 1

HCID 178454398HCID 178454398, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Diisopropylethylamine (0.22 mmol), vinyl acetic acid (0.11 mmol) and benzotriazolyloxy-tris-(dimethylamino)phosphonium-hexafluorophosphate (0.11 mmol) are added successively to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 mL), and the reaction mixture is stirred for 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) there is extraction with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.

후처리

  1. extractionextraction with ethyl acetate

출처 및 근거

ORD 기록
ord-fecbe090558448a4a06f30a565bfc4fc
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727979B2

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