Cyclohexylamine → Ethyl 3-(cyclohexylamino)propanoate
반응식
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13]Cl)[CH3:9].C([O-])([O-])=O.[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13][NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH3:9]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.
후처리
- customThe resulting mixture was then partitioned between water and dichloromethane
- dry with materialThe organic layer was dried (MgSO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-66ca2717a0e24c2293f8cef297ade30e
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728003B2
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