Hydrochloric Acid → N-[2-(4-Methyl-1-oxo-1,2,3,4-tetrahydrobenzo[f]quinolin-10-yl)ethyl]-2-phenylacetamide

HRID 1246412

반응식

HRID 1246412 반응식
[CH3:1][N:2]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[C:11]([CH2:18][CH2:19][NH:20][C:21](=[O:29])[CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[CH2:3][CH2:4][C:5](Cl)=[O:6].[Cl-].[Al+3].[Cl-].[Cl-].Cl>ClC(Cl)C(Cl)Cl>[CH3:1][N:2]1[C:8]2[CH:17]=[CH:16][C:15]3[CH:14]=[CH:13][CH:12]=[C:11]([CH2:18][CH2:19][NH:20][C:21](=[O:29])[CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:10]=3[C:9]=2[C:5](=[O:6])[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 219168293-[Methyl-(8-{2-[(2-phenylacetyl)amino]ethyl}-2-naphthyl)amino]propanoyl Chloride

생성물 1

HCID 9951378N-[2-(4-Methyl-1-oxo-1,2,3,4-tetrahydrobenzo[f]quinolin-10-yl)ethyl]-2-phenylacetamide

시약·촉매·용매 1

HCID 65911,1,2,2-Tetrachloroethane용매

반응 조건

온도
60 °C

실험 절차

The product obtained in Step C (3 mmol), dissolved in 1,1,2,2-tetrachloroethane (30 ml), is added dropwise to a solution of aluminium chloride (10 mmol) in the same solvent (20 ml) under nitrogen. The reaction mixture is heated at 60° C., with stirring, until the reaction has ceased and it is then poured into a mixture of ice (10 g) and concentrated HCl (0.3 ml); stirring is continued for one hour. The aqueous phase is extracted twice with chloroform; the combined organic phases are then dried over magnesium sulphate and concentrated under reduced pressure. The residue is chromatographed on silica gel to yield the title product.

후처리

  1. stirringstirring
  2. extractionThe aqueous phase is extracted twice with chloroform
  3. dry with materialthe combined organic phases are then dried over magnesium sulphate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is chromatographed on silica gel

출처 및 근거

ORD 기록
ord-6ee37953c6d04e8894e0091165d4e7c5
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07126012B2

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