Hydrochloric Acid → 1,4-Bis(3-aminopropyl)piperazine Glutaric Dialdehyde

HRID 1271821

반응식

HRID 1271821 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:7][CH2:6]1.[CH2:15]([CH2:19][CH:20]=[O:21])[CH2:16][CH:17]=[O:18].Cl>O>[NH2:14][CH2:13][CH2:12][CH2:11][N:8]1[CH2:7][CH2:6][N:5]([CH2:4][CH2:3][CH2:2][NH2:1])[CH2:10][CH2:9]1.[CH2:15]([CH2:19][CH:20]=[O:21])[CH2:16][CH:17]=[O:18]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3485GlutaraldehydeHCID 816291,4-Bis(3-aminopropyl)piperazine

생성물 1

HCID 1317263401,4-Bis(3-aminopropyl)piperazine Glutaric Dialdehyde수율 14%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

1,4-Bis(3-aminopropyl)piperazine (206 μL, 0.998 mmol, Aldrich Chemical Company) was taken up in 5.0 mL H2O. Glutaric dialdehyde (206 μL, 0.998 mmol, Aldrich Chemical Company) was added and the solution was stirred at room temperature. After 30 min, an additional portion of H2O was added (20 mL), and the mixture neutralized with 6 N HCl to pH 7, resulting in a red solution. Dialysis against H2O (3×3 L, 12,000–14,000 MWCO) and lyophilization afforded 38 mg (14%) of the copolymer.

후처리

  1. customresulting in a red solution
  2. customDialysis against H2O (3×3 L, 12,000–14,000 MWCO) and lyophilization

출처 및 근거

ORD 기록
ord-492a519d0c24430daba05ab030e65ad3
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208314B2

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