Chloroacetic Acid → HCID 12876168, 화합물

HRID 127295

반응식

HRID 127295 반응식
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].Cl[CH2:15][C:16]([OH:18])=[O:17].[I-].[K+].Cl.[Cl-].[Na+]>C(=O)([O-])[O-].[K+].[K+]>[C:16]([CH2:15][S:8][CH2:7][C@@H:6]([C:9]([OH:11])=[O:10])[NH:5][C:3](=[O:4])[C:2]([S:1][CH2:6][C:9]([OH:11])=[O:10])([CH3:13])[CH3:12])([OH:18])=[O:17]

참가 물질

7

반응물 5

HCID 300Chloroacetic AcidHCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 5234Sodium ChlorideHCID 656604Bucillamine

생성물 1

HCID 12876168HCID 12876168, 화합물수율 194.5%

시약·촉매·용매 1

HCID 11430Potassium Carbonate용매

실험 절차

N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in 1 M potassium carbonate and monochloroacetic acid (11.3 g, 0.12 mol) and potassium iodide (1.0 g) are added. The mixture is stirred overnight at room temperature under a nitrogen atmosphere and acidified with 6 N hydrochloric acid. Sodium chloride is added and the mixture is extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride solution, dried and concentrated to dryness to yield 16.5 g (97.2%) of S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine.

후처리

  1. extractionthe mixture is extracted with ethyl acetate
  2. washThe organic layer is washed with saturated sodium chloride solution
  3. customdried
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-44272a91e41947378530daad8def6fc9
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255446

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