Methane → 5-Bromoimidazo-[1,2-a]-quinoline-2-carboxylic acid

HRID 1277970노트

반응식

HRID 1277970 반응식
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=[C:4]2[CH:3]=1.[OH-].[Na+].Cl.C>O.C(O)C.C(Cl)(Cl)Cl.CO>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=[C:4]2[CH:3]=1

참가 물질

9

반응물 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12763980Ethyl 5-bromoimidazo-[1,2-a]-quinoline-2-carboxylate

생성물 1

HCID 127639795-Bromoimidazo-[1,2-a]-quinoline-2-carboxylic acid

시약·촉매·용매 4

HCID 702Ethanol용매HCID 887Methanol용매HCID 962Water용매HCID 6212Chloroform용매

실험 절차

1.28 g of ethyl 5-bromoimidazo-[1,2-a]-quinoline-2-carboxylate were heated on a steam bath with 5 ml of 1 N sodium hydroxide solution in 20 ml of water and 50 ml of ethanol until a clear solution was obtained (approx. 15 mins). 5 ml of 1 N hydrochloric acid were then added thereto and the solution was allowed to cool slowly to room temperature. The pale green crystals thus formed were filtered off and were washed with methanol. The mother liquors were reduced in volume and cooled to give a second crop. The two crops were combined in 50 ml of chloroform and 50 methanol and the solution obtained was decolorized with charcoal. The solution was reduced in volume under vacuum and the residue was cooled in ice to give colorless plates of 5-bromoimidazo-[1,2-a]-quinoline-2-carboxylic acid melting at 288°-90° C. (decomp).

후처리

  1. customwas obtained (approx. 15 mins)
  2. customThe pale green crystals thus formed
  3. filtrationwere filtered off
  4. washwere washed with methanol
  5. temperaturecooled
  6. customto give a second crop
  7. temperaturethe residue was cooled in ice

출처 및 근거

ORD 기록
ord-1264cf640d914490ad1cae440b157eb7
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279912

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