Tetrahydrofuran → Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate

HRID 1278840

반응식

HRID 1278840 반응식
[C:1]1([C:7]#[C:8][C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][Si:14]([C:17]#[CH:18])([CH3:16])[CH3:15].[CH2:19]1COCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[C:1]1([C:7]([C:18]#[C:17][Si:14]([CH3:16])([CH3:15])[CH3:13])=[CH:8][C:9]([O:11][CH2:12][CH3:19])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 66111TrimethylsilylacetyleneHCID 138378Phenylpropynoic acid methyl ester

생성물 1

HCID 86142661Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate

시약·촉매·용매 1

HCID 167845palladium(II) acetate촉매

실험 절차

A solution of TDMPP (1.4 g) and palladium acetate (700 mg) in THF (200 ml) is stirred for 15 min at room temperature and methyl phenylpropiolate (10 g, 62.5 mmol) is then added. The reaction medium is stirred for 5 min at room temperature and trimethylsilylacetylene (87.5 mmol) is then added. Stirring is continued overnight at room temperature. The reaction medium is concentrated and filtered through silica.

후처리

  1. stirringStirring
  2. waitis continued overnight at room temperature
  3. concentrationThe reaction medium is concentrated
  4. filtrationfiltered through silica

출처 및 근거

ORD 기록
ord-7717bc734c1f4d6da17da5227d18228c
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06444709B1

연결된 노트

불러오는 중…