Hydrochloric Acid → 16-Mercaptohexadecanoic acid

HRID 1279135

반응식

HRID 1279135 반응식
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].NC(N)=[S:22].[OH-].[Na+].Cl>C(O)C>[SH:22][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4111116-Iodohexadecanoic acidHCID 2723790Thiourea

생성물 1

HCID 352258516-Mercaptohexadecanoic acid수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 16-iodohexadecanoic acid (6) (4.0 g, 10.4 mmol) and thiourea (0.88 g, 1.1 equiv.) in ethanol (100 mL) was refluxed overnight under N2 atmosphere. The solution was cooled to room temperature. Sodium hydroxide (1.0 g in 10 mL of water) wad added and the mixture was further heated for 2 hr. After cooling to room temperature 1N HCl was added and the product was extracted using CH2Cl2. The organic extract was dried and evaporated to give a white solid Yield: 2.1 g (69%)

후처리

  1. temperaturewas refluxed overnight under N2 atmosphere
  2. temperaturethe mixture was further heated for 2 hr
  3. additionwas added
  4. extractionthe product was extracted
  5. extractionThe organic extract
  6. customwas dried
  7. customevaporated

출처 및 근거

ORD 기록
ord-48dae631f1574782807114973786c7b2
출처 데이터셋
uspto-grants-2002_09
특허 번호
US06447656B1

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