1,1-Dibromoethane → 2-(2-Bromoethoxy)-1,3-dimethylbenzene
반응식
[OH-].[Na+].[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[OH:11].[Br:12][CH:13](Br)[CH3:14]>O.C(O)C>[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[O:11][CH2:14][CH2:13][Br:12]참가 물질
6
실험 절차
To a solution containing sodium hydroxide (80 g) in water (1 liter) and ethanol (0.5 liter) are added 2,6-dimethyl-phenol (245 g) dissolved in ethanol (0.5 liter), and then dibromoethane (750 g). The mixture is refluxed for 48 hours, under vigorous stirring. It is then extracted with methylene chloride. After washing with dilute aqueous sodium hydroxide and then with water, the solvent is evaporated in vacuo. 2(2,6-Dimethyl-phenoxy)-1-bromo-ethane boils at 148°-150° C./25 mm Hg.
후처리
- temperatureThe mixture is refluxed for 48 hours, under vigorous stirring
- extractionIt is then extracted with methylene chloride
- washAfter washing with dilute aqueous sodium hydroxide
- customwith water, the solvent is evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-7b9296f09277488298a19d66a77727f6
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04259334
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