1,1-Dibromoethane → 2-(2-Bromoethoxy)-1,3-dimethylbenzene

HRID 128204

반응식

HRID 128204 반응식
[OH-].[Na+].[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[OH:11].[Br:12][CH:13](Br)[CH3:14]>O.C(O)C>[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[O:11][CH2:14][CH2:13][Br:12]

참가 물질

6

반응물 3

HCID 112011,1-DibromoethaneHCID 113352,6-DimethylphenolHCID 14798Sodium Hydroxide

생성물 1

HCID 24522082-(2-Bromoethoxy)-1,3-dimethylbenzene

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

To a solution containing sodium hydroxide (80 g) in water (1 liter) and ethanol (0.5 liter) are added 2,6-dimethyl-phenol (245 g) dissolved in ethanol (0.5 liter), and then dibromoethane (750 g). The mixture is refluxed for 48 hours, under vigorous stirring. It is then extracted with methylene chloride. After washing with dilute aqueous sodium hydroxide and then with water, the solvent is evaporated in vacuo. 2(2,6-Dimethyl-phenoxy)-1-bromo-ethane boils at 148°-150° C./25 mm Hg.

후처리

  1. temperatureThe mixture is refluxed for 48 hours, under vigorous stirring
  2. extractionIt is then extracted with methylene chloride
  3. washAfter washing with dilute aqueous sodium hydroxide
  4. customwith water, the solvent is evaporated in vacuo

출처 및 근거

ORD 기록
ord-7b9296f09277488298a19d66a77727f6
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259334

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