Hydrochloric Acid → 2-Methyl-2-(4-methylphenyl)propanoic acid
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[C:9]#N)=[CH:4][CH:3]=1.[OH-:13].[Na+].C(O)C[O:17]CCO.Cl>O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[C:9]([OH:17])=[O:13])=[CH:4][CH:3]=1참가 물질
6
실험 절차
A solution of 2-(4-methylphenyl)-2-methylpropionitrile (53.61 g), sodium hydroxide (40.4 g), diethylene glycol (160.8 ml) and water (60.6 ml) was refluxed for 18 hr. The reaction mixture was poured into water (3000 ml) and conc. hydrochloric acid (90 ml) was added. The generated crystals were collected by filtration to give the title compound (60.0 g) as pale-brown crystals, m.p.=78-81° C.
후처리
- additionwas added
- filtrationThe generated crystals were collected by filtration
출처 및 근거
- ORD 기록
- ord-0636ae7279c74635a7af00ce486818ba
- 출처 데이터셋
- uspto-grants-2002_09
- 특허 번호
- US06455528B1
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