Hydrochloric Acid → 3-Chloro-4-methoxybenzoyl chloride

HRID 1283641

반응식

HRID 1283641 반응식
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([Cl:12])[CH:5]=1.[OH-].[Na+].[ClH:16]>O>[Cl:12][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[O:10][CH3:11])[C:3]([Cl:16])=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 123469Methyl 3-chloro-p-anisate

생성물 1

HCID 47692993-Chloro-4-methoxybenzoyl chloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 10.4 g. (0.052 mol.) of 3-chloro-4-methoxybenzoic acid methyl ester and 3.5 g. (0.09 mol.) of sodium hydroxide in 150 ml. of water was refluxed for two hours. The reaction mixture was cooled and acidified with 10% aqueous hydrochloric acid to precipitate 3-chloro-4-methoxybenzoic acid, m.p. 199°-202°. The acid was refluxed with thionyl chloride as described in the procedure of Example 9 to give 3-chloro-4-methoxybenzoic acid chloride, m.p. 55°-57°.

후처리

  1. additionA mixture of 10.4 g
  2. temperatureThe reaction mixture was cooled
  3. customto precipitate 3-chloro-4-methoxybenzoic acid, m.p. 199°-202°
  4. temperatureThe acid was refluxed with thionyl chloride

출처 및 근거

ORD 기록
ord-3d84c3f678a24b7e9b92c4cbcf018d63
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975537

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