Methyl acetoacetate → Methyl 2-((dimethylamino)methylene)-3-oxobutanoate

반응식

[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:8][O:7][C:1](=[O:6])[C:2](=[CH:11][N:12]([CH3:14])[CH3:13])[C:3](=[O:4])[CH3:5]

참가 물질

반응물 2

HCID 7757Methyl acetoacetate

HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 53395488Methyl 2-((dimethylamino)methylene)-3-oxobutanoate수율 94%

반응 조건

온도: 25 °C

실험 절차

A solution of methyl acetoacetate (5.0 mL, 46.33 mmol) and N,N-dimethylformamide dimethylacetal (6.8 mL, 47.95 mmol) was heated to 80° C. for 2.3 h. At this time, the reaction was cooled to 25° C. and was then concentrated in vacuo to afford 2-dimethylaminomethylene-3-oxo-butyric acid methyl ester (7.43 g, 94%) as a red/black solid. This material was used without further purification.

후처리

concentrationwas then concentrated in vacuo

출처 및 근거

ORD 기록: ord-7ab93d08bb4a4e4f9f6760fb3038c041
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07728029B2

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