1-Bromo-2-fluorobenzene → 5-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile

HRID 130008

반응식

HRID 130008 반응식
Cn1cnc(C#N)c1.Fc1ccccc1Br>C=C[CH2-].C=C[CH2-].CC(=O)N(C)C.CC(=O)[O-].[Cl][Pd+].[Cl][Pd+].[K+].c1ccc(P(c2ccccc2)C2CCCCC2)cc1>Cn1cnc(C#N)c1-c1ccccc1F

참가 물질

9

반응물 2

HCID 612591-Bromo-2-fluorobenzeneHCID 27951151-Methyl-1H-imidazole-4-carbonitrile

생성물 2

HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 841174465-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile수율 29.4%

시약·촉매·용매 5

HCID 517044Potassium Acetate시약HCID 61538Palladium, di-mu-chlorobis(eta3-2-propenyl)di-촉매HCID 80756Phosphine, cyclohexyldiphenyl-촉매HCID 31374Dimethylacetamide용매HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

반응 조건

온도
105 °C

후처리

  1. additionThe plate was removed from the glovebox, opened, and diluted to a 900 uL total volume with N,N-dimethylacetamide. The plate was stirred for 5 min and a 75 uL sample was taken and filtered into an HPLC analysis plate. The filter was rinsed with 400 uL acetonitrile/water (4:1) solution and analyzed by UHPLCMS
  2. stirring기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationorganic 상 유지

출처 및 근거

ORD 기록
ord-c9631c1699f34714a2dfba99b907113a
출처 데이터셋
Shields Arylation

연결된 노트

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