Methyl iodide → 4-Methylheptane-3,5-dione

HRID 132721

반응식

HRID 132721 반응식
[H-].[Na+].O1CCC[CH2:4]1.[CH3:8][CH2:9][C:10](=[O:16])[CH2:11][C:12](=[O:15])[CH2:13][CH3:14].IC>O>[CH3:4][CH:11]([C:10](=[O:16])[CH2:9][CH3:8])[C:12](=[O:15])[CH2:13][CH3:14]

참가 물질

6

반응물 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 819233,5-Heptanedione

생성물 1

HCID 30139824-Methylheptane-3,5-dione수율 94%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 0.02 mol sodium hydride was added 100 ml anhydrous tetrahydrofuran, slowly added dropwise 0.02 mol 3,5-heptandione at room temperature. Upon completion, the mixture was stirred for 0.5 hours, then 0.04 mol iodomethane was slowly added dropwise. After stirred at room temperature for 10 hours, 20 ml water was added. White solid was precipitated. The solid was filtered, washed with water, and dried to give 4-methyl-3,5-heptandione as a white solid, and the yield was 94%. m.p. was 91-92° C.

후처리

  1. stirringAfter stirred at room temperature for 10 hours
  2. customWhite solid was precipitated
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-215ad9bed3a34087a85ae1671f74959f
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388061B2

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