Hydrochloric Acid → Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

HRID 133180노트

반응식

HRID 133180 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[H-].[Na+].Cl.[CH:18](OCC)=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:18][OH:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 11481060Ethyl 2-(3,5-difluorophenyl)acetate

생성물 1

HCID 67388060Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

실험 절차

5.0 g of ethyl 3,5-difluorophenylacetate are dissolved in 50 ml of ethyl formate. 2.0 g of 60% NaH are added portionwise. The mixture is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. The residue is triturated in petroleum ether, the remaining white precipitate is filtered off and then the filtrate is evaporated to produce 3.3 g of the expected compound in the form of a liquid.

후처리

  1. extractionextraction
  2. customThe residue is triturated in petroleum ether
  3. filtrationthe remaining white precipitate is filtered off
  4. customthe filtrate is evaporated

출처 및 근거

ORD 기록
ord-dab81ae7a179419f995200fdce64b5a8
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390818B2

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