Water → 1-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene

HRID 1350192

반응식

HRID 1350192 반응식
[C:1]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]1=O)([O:3][CH3:4])=[O:2].C(O)(=O)C(C)C.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.O>C1(C)C=CC=CC=1>[C:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]=1[NH:29][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([O:3][CH3:4])=[O:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6590Isobutyric AcidHCID 7504BenzylamineHCID 5991311-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-2-oxo-, methyl ester

생성물 1

HCID 210946731-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene수율 102.4%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 1-carbomethoxy-2-oxo-1,2,3,4-tetrahydronaphthalene (10.2 g) and isobutyric acid (4.84 g) in toluene (150 mL) stirring at room temperature under argon, was added benzylamine (5.35 g). The resulting mixture was heated to reflux for 2 h with water removal using a Dean-Stark trap. The solvent was then evaporated under vacuum to provide the title compound (15 g) as a yellow gum.

후처리

  1. temperatureThe resulting mixture was heated
  2. customThe solvent was then evaporated under vacuum

출처 및 근거

ORD 기록
ord-e1562b7a1b0342efa5869dca9cb48120
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214704B2

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