Hydrochloric Acid → N-Methacryloylalanine
반응식
[OH-].[Na+].[NH2:3][C@H:4]([C:6]([OH:8])=[O:7])[CH3:5].[C:9](Cl)(=[O:13])[C:10]([CH3:12])=[CH2:11].Cl>O.C1COCC1>[C:9]([NH:3][C@H:4]([C:6]([OH:8])=[O:7])[CH3:5])(=[O:13])[C:10]([CH3:12])=[CH2:11]참가 물질
7
실험 절차
Sodium hydroxide (1.24 g) and L-alanine (2.76 g) were dissolved in pure water and, under cooling with ice, a solution where methacryloyl chloride (3 ml) was dissolved in THF (15 ml) and an aqueous solution (17 ml) containing sodium hydroxide (1.21 g) were simultaneously dropped thereinto. After that, the mixture was stirred at room temperature for 4 hours, acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organic phase was dried, concentrated in vacuo, washed with ether and dried in vacuo to give an aimed product. Yield was 1.76 g (36%).
후처리
- temperatureunder cooling with ice
- additionwere simultaneously dropped
- extractionextracted with ethyl acetate
- customThe organic phase was dried
- concentrationconcentrated in vacuo
- washwashed with ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-4b71dbe6b469430f8ac588c2ff6d69c9
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07892834B2
반응 노트
불러오는 중…