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Dimethylformamide → 9-Phenyl-9H-carbazole-3-carboxaldehyde

HRID 1369369
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인쇄 미리보기

반응식

HRID 1369369 반응식
[C:1]1([N:7]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:13]3[C:8]2=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)(Cl)=O.CN([CH:28]=[O:29])C>ClC(Cl)C.Cl>[C:1]1([N:7]2[C:8]3[CH:9]=[CH:10][C:11]([CH:28]=[O:29])=[CH:12][C:13]=3[C:14]3[C:19]2=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 708519-Phenylcarbazole

생성물 1

HCID 185154409-Phenyl-9H-carbazole-3-carboxaldehyde

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 63651,1-Dichloroethane용매

반응 조건

온도
40 °C

실험 절차

To 0.49 g of N-phenylcarbazole in 2 mL of dichloroethane is added 0.19 mL of phosphorus oxychloride and 0.5 mL of DMF. The resulting mixture is stirred at 40° C. overnight. After stirring, 1 mL of 1 M HCl is added. After 5 additional minutes, the mixture is diluted with 1 M HCl and extracted with ethyl acetate. The crude product is purified by column chromatography on silica gel to give 60 mg of Compound 7.

후처리

  1. stirringAfter stirring
  2. extractionextracted with ethyl acetate
  3. customThe crude product is purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-4cca24318bbc4925bc21d2465003b4e1
출처 데이터셋
uspto-grants-2003_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06579718B1

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