Propylamine → N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinazolinyl]oxy}-2-chlorophenyl)-N'-propylurea

HRID 1375778

반응식

HRID 1375778 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:26]=[CH:25][C:23]([NH2:24])=[C:22]([Cl:27])[CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:28][CH3:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.ClC(Cl)(O[C:41](=[O:47])OC(Cl)(Cl)Cl)Cl.[CH2:49]([NH2:52])[CH2:50][CH3:51]>C(Cl)(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:26]=[CH:25][C:23]([NH:24][C:41]([NH:52][CH2:49][CH2:50][CH3:51])=[O:47])=[C:22]([Cl:27])[CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:28][CH3:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 7852PropylamineHCID 8471TriethylamineHCID 94429TriphosgeneHCID 226672324-{[7-(Benzyloxy)-6-methoxy-4-quinazolinyl]oxy}-2-chloroaniline

생성물 1

HCID 22667035N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinazolinyl]oxy}-2-chlorophenyl)-N'-propylurea수율 63%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

4-{[7-(Benzyloxy)-6-methoxy-4-quinazolinyl]oxy}-2-chloroaniline (12.2 g) was dissolved in anhydrous chloroform. Triethylamine (8.4 ml) was then added to the solution, and the mixture was stirred at room temperature. Separately, triphosgene (4.5 g) was dissolved in anhydrous chloroform (12 ml), and the solution was added dropwise to the mixed solution. The mixture was stirred at room temperature for 20 min, and n-propylamine (4.9 ml) was then added thereto, followed by stirring at room temperature for additional one hr to precipitate a white solid. This solid was collected by filtration and was then washed with chloroform to give 9.4 g (yield 63%) of the title compound.

후처리

  1. additionthe solution was added dropwise to the mixed solution
  2. stirringThe mixture was stirred at room temperature for 20 min
  3. stirringby stirring at room temperature for additional one hr
  4. customto precipitate a white solid
  5. filtrationThis solid was collected by filtration
  6. washwas then washed with chloroform

출처 및 근거

ORD 기록
ord-263184a99e0f44e3a30224fdb6040f40
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07169789B2

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