Hydrochloric Acid → 4-Nitro-3-phenylheptanedioic acid dimethyl ester

HRID 1380930

반응식

HRID 1380930 반응식
[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][N+:7]([O-:9])=[O:8].[C:17]([O:21][CH3:22])(=[O:20])[CH:18]=[CH2:19].Cl>C(O)(C)(C)C.C(OCC)C>[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH:5]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH:6]([N+:7]([O-:9])=[O:8])[CH2:19][CH2:18][C:17]([O:21][CH3:22])=[O:20]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 7294Methyl AcrylateHCID 10537045Benzenepropanoic acid, b-(nitromethyl)-, methyl ester

생성물 1

HCID 136492464-Nitro-3-phenylheptanedioic acid dimethyl ester

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6386tert-Butanol용매

실험 절차

A solution of 356 g of 4-nitro-3-phenylbutanoic acid methyl ester, 138 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate and evaporated to give 4-nitro-3-phenylheptanedioic acid dimethyl ester.

후처리

  1. customThe organic layer is separated
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-3f4c7e6ec30141ae967858d614e0af35
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04584313

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