Formamide → 2-[4-[4-(Pyrimidin-4-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione

HRID 1417318

반응식

HRID 1417318 반응식
[C:1]([C:4]1[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]2=[O:23])=[CH:6][CH:5]=1)(=O)[CH3:2].[CH:26]([NH:28][CH:29](NC=O)[NH:30]C=O)=O.C(N)=O.[OH-].[Na+]>O>[N:28]1[CH:26]=[CH:2][C:1]([C:4]2[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]3[C:21](=[O:22])[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:14]3=[O:23])=[CH:6][CH:5]=2)=[N:30][CH:29]=1

참가 물질

6

반응물 4

HCID 713FormamideHCID 14798Sodium HydroxideHCID 78505N,N',N''-MethylidynetrisformamideHCID 675980872-[4-(4-Acetylphenoxy)butyl]-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 675995062-[4-[4-(Pyrimidin-4-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 10.0 g of 2-[4-(4-acetylphenoxy]-butyl]-1H-isoindole-1,3(2H)-dione (Example 42) 10.0 g of tris(formamido)methane, and 20 ml of formamide are combined and the mixture stirred and heated at 160°-165° C. for 8 hours. After dilution with 100 ml of water, the mixture is rendered basic with 10N NaOH, the precipitate collected, washed with water, and air dried. Recrystallization from ethanol gives the pure compound, m.p. 100°-102° C.; yield, 5.0 g.

후처리

  1. temperatureheated at 160°-165° C. for 8 hours
  2. customthe precipitate collected
  3. washwashed with water, and air
  4. customdried
  5. customRecrystallization from ethanol
  6. customgives the pure compound, m.p. 100°-102° C.
  7. customyield

출처 및 근거

ORD 기록
ord-14a0374f1cf0424bb6cd26c83a98c3ef
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877196

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