Hydrochloric Acid → 2,3-Difluoro-6-methoxyphenol

HRID 1418782

반응식

HRID 1418782 반응식
[F:1][C:2]1[CH:3]=[C:4]([O:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[Li+].CCC[CH2-].C[O:17]B(OC)OC.Cl.OO>CCCCCC>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([O:9][CH3:10])[C:3]=1[OH:17]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 8470Trimethyl borateHCID 61028n-Butyl lithiumHCID 5682503,4-Difluoroanisole

생성물 1

HCID 32697282,3-Difluoro-6-methoxyphenol

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Using the procedure of Example 39, 125 g of 3,4-difluoroanisole (commercial) and 500 ml of a 1.6M solution of N-butyllithium in hexane were reacted at -72° C., and then 92.4 ml of trimethylborate, 500 ml of hydrochloric acid and 120 g of intermediate compound were reacted and the product was reacted with 440 ml of 30% hydrogen peroxide to obtain 82.4 g of the expected product melting at 46.6° C.

후처리

  1. customwere reacted at -72° C.

출처 및 근거

ORD 기록
ord-e1f81f1f89b64b9b91adfe61beacbb94
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05883248

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