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Bromide ion → HCID 57660935, 화합물

HRID 1424318
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HRID 1424318 반응식
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:17][CH:18]1[CH2:22][NH:21][C:20](=[O:23])[CH2:19]1.[H-].[Na+].[Na].[Br-]>CN(C=O)C>[C:1]([O:5][C:6](=[O:15])[N:7]([C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=1)[CH2:17][CH:18]1[CH2:19][C:20](=[O:23])[NH:21][CH2:22]1)([CH3:4])([CH3:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 259Bromide ionHCID 24758Sodium hydrideHCID 5360545SodiumHCID 11063648tert-butyl N-(4-methylpyridin-2-yl)carbamateHCID 179489684-(Bromomethyl)pyrrolidin-2-one

생성물 1

HCID 57660935HCID 57660935, 화합물

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

(4-Methylpyridin-2-yl)carbamic acid tert-butyl ester was alkylated with 4-bromomethylpyrrolidin-2-one by deprotonation in DMF at 0° C. with NaH and treating the sodium salt with the bromide at room temperature. After dilution of the reaction mixture with ethyl acetate and washing with saturated aqueous NaHCO3 the crude product was purified by chromatography on silica gel (ethyl acetate/hexane) to yield (14) as yellow oil.

후처리

  1. washAfter dilution of the reaction mixture with ethyl acetate and washing with saturated aqueous NaHCO3 the crude product
  2. customwas purified by chromatography on silica gel (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-ac31adea32784761bff93c5d37baa03f
출처 데이터셋
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08927534B2

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