Benzene → 1-Phenyl-2-propen-1-one

HRID 1428424노트

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HRID 1428424 반응식
[CH:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:7](Cl)(=[O:10])[CH:8]=[CH2:9].[Cl-].[Al+3].[Cl-].[Cl-].Cl>ClCCl>[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:10])[CH:8]=[CH2:9]

참가 물질

6

반응물 4

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 13140Acryloyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 130281-Phenyl-2-propen-1-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
0 °C

실험 절차

Benzene (1 mL), acryloyl chloride (0.4 mL), and aluminium chloride (0.33 g) were added to dichloromethane (4 mL), followed by stirring at 0° C. for 2 hours. After reaction, 1 N hydrochloric acid and dichlormethane (5 mL) were added in order. The organic phase was concentrated. The obtained residue was applied to a silica gel column to obtain the title compound (120 mg).

후처리

  1. additionwere added in order
  2. concentrationThe organic phase was concentrated

출처 및 근거

ORD 기록
ord-705956e2f9754b308b883e365c03e0ab
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937091B2

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